We’ve recently submitted a meta-analysis investigating how women’s health-related risks change across the menstrual cycle (https://psyarxiv.com/k8s5y/). The hormonal cycle is known to impact a wide ranges of behaviors and cognitive skills among non-human mammals. One of the robust findings in the neuroendocrinology of animal is the increase of sexual activity at the time of estrus compared to the rest of the cycle. While certains species display extended sexuality, this estrus shift is well-consistent across time and inter-species comparisons. However, among human beings, the debate is still open to know if, despite the extreme women’s extended sexuality, a slight increase could be observed at mid-cycle compared to the rest of the cycle. We tried to generate hypothesis connecting the animal and human litterature (see figure below for a comparisons between the estrous cycle of rodents [a] and the human menstrual cycle [b]).